Variability of HPLC and MS Laboratory Analysis Results
TL;DR: Laboratory analysis results can differ even for the same test material, because methods such…
PT-141
Cyclic heptapeptide · MC3R/MC4R agonist · CAS 189691-06-3
Purity ≥98% HPLC Analysis Warehouse in Poland
129,00 PLN
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Cold storage at -20°C
Certificate of Analysis (CoA)
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For research use only. Not for human use.
Wyłącznie do celów badawczych. Nie do użytku ludzkiego.
Wyłącznie do celów badawczych. Nie do użytku ludzkiego.
Product Description
Physicochemical Properties
| Parameter | Value |
|---|---|
| Molecular formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular weight | 1025.2 Da |
| Amino acid count | 7 (cyclic heptapeptide) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| CAS number | 189691-06-3 |
| PubChem CID | 9941379 |
| Physical form | White lyophilized powder |
| Purity | ≥98% (RP-HPLC) |
| Classification | Chemical reagent / research material |
| Intended use | For in vitro research use only, not for use in humans or animals |
Offered as a chemical reagent for in vitro laboratory use, within the framework of applicable European Union chemical substances regulations (REACH, CLP).
In Vitro Laboratory Use
Reconstitution and storage conditions:
- Dissolve in sterile water or phosphate buffer (recommended pH 6.0–7.4); working concentration per analytical protocol
- Storage of unreconstituted powder: −20 °C, dry location, protected from light
- After reconstitution: aliquots in microtubes, single thaw, short-term storage at 2–8 °C
Typical analytical equipment:
- HPLC column dedicated to peptide analysis (e.g., C18, 150–250 mm)
- HPLC system with detector (UV 220 nm, FLD or MS — depending on protocol)
- Autosampler vials, laboratory test tubes, precision pipettes
- Analytical balance with ≥0.1 mg accuracy for sample weighing
All working parameters should be selected according to the research laboratory’s internal protocol. Product intended exclusively for in vitro and analytical use; not for human or animal use.
Scientific Research & Details
Expand research overview
Scientific Research & Details
Expand research overviewMolecular Mechanism
PT-141 is a cyclic heptapeptide and synthetic analog of alpha-melanotropin (alpha-MSH). Structurally, it is an active metabolite of Melanotan II, differing by the absence of an amide group at the C-terminus. PT-141 acts as a non-selective melanocortin receptor agonist, with affinity for MC1R, MC3R, MC4R, and MC5R subtypes, while showing no activity at the MC2R (ACTH) receptor.
In in vitro and animal model studies, activation of MC4R in the central nervous system was shown to modulate signaling pathways related to neuroendocrine functions. The cyclic lactam structure confers increased proteolytic stability compared to linear melanocortin analogs.
PT-141 vs Melanotan II
PT-141 and Melanotan II are structurally related melanocortin peptides with different pharmacological profiles. PT-141 is the active metabolite of Melanotan II, formed by removal of the C-terminal amide group.
| Feature | PT-141 | Melanotan II |
|---|---|---|
| Structure | Cyclic heptapeptide (lactam) | Cyclic heptapeptide (lactam) |
| Molecular weight | 1025.2 Da | 1024.2 Da |
| Target receptors | MC1R, MC3R, MC4R, MC5R | MC1R, MC3R, MC4R, MC5R |
| MC2R receptor | No activity | No activity |
| Primary research profile | MC4R pathways in CNS | MC1R (melanogenesis) + MC4R pathways |
| CAS number | 189691-06-3 | 121062-08-6 |
Stability and Storage
In lyophilized form, store PT-141 at -20°C for long-term stability. After reconstitution in sterile water, the solution remains stable for up to 30 days at 2-8°C. The cyclic lactam structure provides higher resistance to enzymatic degradation compared to linear melanocortin peptides.
Related Research Materials
PT-141 belongs to the melanocortin peptide family, which also includes Melanotan II and other alpha-MSH analogs. The cyclic lactam structure of PT-141 exemplifies a modification that enhances proteolytic stability of linear peptides.
Bibliography
1 scientific publication
Bibliography
1 scientific publicationSelected publications on PT-141 (Bremelanotide) and melanocortin peptides.
"PT-141: a melanocortin agonist for the treatment of sexual dysfunction"
Annals of the New York Academy of Sciences, 994:96-102
Regulatory Information and Storage Conditions
Expand
Regulatory Information and Storage Conditions
ExpandIntended Use
This product is a chemical raw material intended exclusively for in vitro research, scientific, and analytical applications. It is not intended for human or veterinary use, including for diagnostic, therapeutic, prophylactic, or nutritional purposes.
Handling
- Work in laboratory conditions consistent with Good Laboratory Practice (GLP) principles.
- Use appropriate personal protective equipment: nitrile gloves, safety goggles, lab coat.
- Avoid inhalation of dust and contact with skin or mucous membranes.
- Work in a well-ventilated area.
Regulatory Classification
This product is not classified as a hazardous substance under CLP Regulation (EC) No 1272/2008. It is offered as a chemical reagent within the framework of applicable European Union chemical substances regulations (REACH, CLP). It does not constitute a medicinal product, dietary supplement, medical device, or cosmetic within the meaning of applicable laws.
Disposal
Unused material should be disposed of in accordance with local regulations on chemical waste. Under laboratory conditions: neutralize and dispose with laboratory waste streams. Do not discharge into sewage systems.
Regulatory Information
This product is offered in accordance with applicable European Union regulations on chemical substances (REACH, CLP) and Polish law governing the trade of chemical reagents and research materials. Full terms of sale and product classification are set out in the Terms of Service.
By placing an order, the Customer confirms having read the above information and accepts the provisions of the Terms.
Product-Specific Notes
PT-141 (Bremelanotide) is an active metabolite of Melanotan II and a non-selective melanocortin receptor agonist. Research literature has documented adverse events associated with MC4R activation, including cardiovascular effects (in particular elevated blood pressure) and neuroendocrine functions. The substance requires handling in accordance with the internal laboratory protocol. Research substance — not intended for use in humans or animals.
Safety Contact
For questions regarding handling or regulatory information: [email protected].
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Frequently Asked Questions
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It acts as an agonist at melanocortin receptors MC1R, MC3R, MC4R, and MC5R, with preference for MC4R pathways in the CNS.
PT-141 is a metabolite of Melanotan II with greater selectivity for MC3R/MC4R over MC1R. Melanotan II is a broader melanocortin agonist affecting MC1R/MC3R/MC4R/MC5R. Both are cyclic heptapeptides derived from alpha-MSH.
Store lyophilized PT-141 at -20°C to -80°C, protected from light. After reconstitution, store at 2-8°C and use within 30 days.
PT-141 is available as a 10 mg lyophilized vial.
Every batch undergoes RP-HPLC analysis (≥98%) and mass spectrometry verification. Certificate of Analysis included.